Dear Future Centenarian,

Nearly everyone on this planet spends their lives fretting or burning lots and lots of time, emotion and energy on external events over which they have ZERO control.

So, these events control them.

There are hundreds of examples, so let’s just visit a few of the more common and destructive before we get into how this phenomenon shortens lives.

One of the more acute examples is politics, especially last year.

How much time did you spend glued to a screen watching the news, often getting irritated or depressed? Then, were you guilty of then spending hours discussing the day’s events with others?

I know, I was guilty of that, even though I thought I knew better. So, what was my payoff? Was I healthier, richer, happier, smarter? Far from it.

I have no idea how many hours that habit chewed up that I could have invested in my health, wealth, happiness, and education… even though I did manage to limit the time I wasted on a negative pursuit.

I know people who spent the better part of every day consumed by the news and activities that could not possibly bear them any fruit. All their focus, sometimes anguish and related stress cost them in ways they will never recoup, regardless of whether or not their side won.

And political related activities cost many people their lives.

I did catch myself before I got overly engrossed and cut way back on something totally out of my control.

I didn’t turn into an ostrich. I still read the headlines and an occasional news article in order to keep informed, but now I refuse to watch news broadcasts and getting drawn into long fruitless political discussions.

Mine was a hard habit to break, and I was only partially addicted. I suggest you do the same. Channeling my thoughts and efforts back into work and relationships felt like getting out from under a huge destructive burden.

Bottom line is… I’m happier and more relaxed.

I spent some time here on the political example, but the same applies to the weather, pollution, taxes, your boss’ abrasive personality, crime, disturbances in far-away places, pandemics, worries over what might happen, growing old, etc.

If you’re constantly bothered by the weather where you live, move if possible. If not, adjust to it.

Don’t pollute. You have no control over what the rest of the world does.

If taxes are an issue, get a tax planner, or again, move to a tax friendly jurisdiction. Then don’t dwell on the burden that the whole world shares.

If your boss causes you stress, consider transferring to another department or finding a more rewarding job.

Crime has always plagued civilization. So, live in as safe a place as you can afford and do your best to burglar-proof your home.

Upheavals in distant lands sell media advertising, but getting sucked into following those daily events or not is your choice. Read the headlines if you must and then go read an enjoyable book.

Pandemics? So much negative news. Take precautions. You know what they are. Then get back to rewarding activities.

Do you worry about what destructive things might happen in the future? Your fears are rarely justified, so plan your future, live in the moment, and realize major events will or won’t happen regardless of your worries.

A rare few can potentially influence some of these issues. Nanotechnology scientists will almost certainly solve pollution and even hunger problems. I’m just not one of them. So, I’m more than content to benefit from these nanotech and other technologies that the rare few build.

This leaves “growing old.”

You will not be able to reverse time’s arrow. What you can do is take control of your response to aging. Most respond by worrying or complaining about it. They see nothing but the negative aspects. Others take it in stride and age with a good attitude, looking forward to retirement and to spending time with grandchildren.

Almost everyone is resigned to aging, thinking there is nothing they can do about it.

However, times have changed. Instead of a certain slow decline ending in death, hope is on the horizon. Other rare few are developing medical “miracles” to actually reverse the human aging process.

And that, future centenarian, empowers you as an individual to take control of your lifestyle habits so that you can live long enough to benefit from those miracles once fully developed.

It’s easier than you may think, it could happen sooner than you think, and you are special in the respect that no one in history until now has had your opportunity.

It won’t be long before my seven e-books that give you step-by-step guidance will be published. They’ll be on Amazon, but you will get them at no charge since you subscribe to this newsletter.

Stay tuned.

More Life,
David Kekich



Weekly News

Selectively Targeting Atherosclerosis-Related Inflammatory Signaling

Chronic, unresolved inflammation is a feature of aging, and an important contributing cause of many age-related conditions.

It is an inappropriate and damaging overactivation of the immune system, provoked by senescent cell signaling and various other forms of cell and tissue damage characteristic of aging. Why not just work to consistently suppress inflammation, then?

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A Cautious View of Senolytics from the Cancer Research Community

Today’s open access publication is an examination of therapy induced senescence in the treatment of cancers, and the role that senolytic therapies might play in cancer therapy.

Senolytic therapies selectively destroy senescent cells, which accumulate with age but are also created in sizable numbers by chemotherapy and radiotherapy.

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Economic Research on Treating Aging to Extend Healthy Longevity

In one sense, there is an enormous wealth of research on the economics of longer lives. This is a byproduct of the operations of sizable pensions and life insurance industries, dependent as they are on successfully predicting future trends in life span.

On the other hand, outside this somewhat narrow scope, most concerned with the gain of a tenth of a year here and the loss of a tenth of a year there, there is comparatively little economic work that is directly tied to the research and advocacy communities engaged in trying to treat aging and greatly lengthen healthy human lifespan.

That will change as the longevity industry both grows and succeeds in introducing age-slowing and rejuvenating therapies into the clinic.

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Profiling IntraClear, Aiming to Break Down Lipofuscin in Aged Cells

The Russian and Eastern European longevity community is quite active, with a number of non-profit organizations such as the Science for Life Extension Foundation and Open Longevity.

There is arguably a greater interest in engineering greater longevity in that part of the world than in the English-language regions. That said, I would say they are behind the US-centric longevity community in terms of translating patient advocacy and scientific programs into startup biotech companies.

Their successes to date include the clinical development of mitochondrially targeted antioxidants, the small molecule discovery company Gero, as well as less directly relevant groups such as the Estonian Haut.AI. Today, I’ll note another Estonian project, IntraClear Biologics, an early stage venture focused on clearance of lipofuscin and other forms of harmful metabolic waste.

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Upregulation of Autophagy via mTOR Inhibition Reduces Tendon Stem Cell Senescence

One of the more interesting studies of cellular senescence in recent years was the demonstration that topical treatment with rapamycin, an inhibitor of mTOR signaling, over a period of months meaningfully reduced the burden of cellular senescence in the skin of aged individuals, leading to improvement in skin quality.

It did not achieve this goal by directly destroying senescent cells, as rapamycin is not a senolytic drug. It acts instead to prevent some damaged cells from becoming senescent, or blunt the accumulation of damage in some vulnerable cells, or otherwise reduce the pace at which cells become senescent.

That in turn means that senescent cell clearance must still be operational even in very old people: the aged immune system can destroy these cells, it is just falling behind.

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Towards a Cure for Aging

Work on treating aging as a medical condition, targeting the mechanisms that cause aging in order to slow or reverse its progression, has advanced to the point at which the popular science and medical resources of the world are writing overviews on the topic, seeking to better inform the public at large.

We have come a long way in the past decade. The compelling animal data for approaches such as the targeted removal of senescent cells, showing rejuvenation in mice, is melting some of the skepticism that previously characterized attitudes towards the treatment of aging.

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SIRT3 Upregulation as a Treatment for Lung Fibrosis

Fibrosis is a malfunction of tissue maintenance in which excessive scar-like collagen deposits disrupt tissue structure and function. This may be one of the consequences of the chronic inflammation of aging, and senescent cell accumulation is implicated in the progression of fibrosis.

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Investigating the Mechanisms by which PAPP-A Inhibition Extends Life

Inhibition of PAPP-A is one of the many interventions capable of slowing aging in mice. Being able to slow aging and understanding how exactly that outcome is achieved are two very different things, however.

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Data on the Effects of Fecal Microbiota Transplant Between Genders and Ages in Mice

The gut microbiome changes with age, losing populations that produce beneficial metabolites, and gaining populations that produce chronic inflammation and other harms. There are many possible contributions to this process of aging, but it is unclear as to which of them are important.

It has been shown in animal studies that performing fecal microbiota transplantation from young to old individuals restores a more youthful gut microbiome for an extended period of time, improving health and extending life span. Researchers here add more data for the short term outcomes of fecal microbial transplantation in mice.

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Calico, As Expected, is Working on Low Yield Projects in Aging

Calico represents a sizable investment in research and development related to aging and age-related disease. Unfortunately, all the signs have pointed towards this effort going into projects that cannot possibly do more than very modestly affect aging.

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The Gut Microbiome Becomes More Uniquely Dysfunctional with Age from Individual to Individual

The gut microbiome changes with age, and these changes are implicated in the progression of aging, such as via loss of beneficial metabolites produced by microbial species, or by chronic inflammation generated by harmful microbes when present in greater numbers.

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Bile Duct Organoids as an Approach to Liver Repair

As Lygenesis is in the process of demonstrating, transplantation of functional liver tissue in the form of lab-grown organoids can restore enough lost liver function to make a meaningful difference to patients.

Lygenesis transplants into lymph nodes, while the numerous other groups engaged in the production of liver organoids are focused on adding new liver tissue directly to the existing liver.

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Investment in the Longevity Industry is Growing

The longevity industry is focused on the production of therapies that target mechanisms of aging. The goal is to slow the progression of aging by making metabolism more resistant to the damage that is present in old tissues, or, better, to produce rejuvenation in the old by repairing that damage.

The laboratory data of recent years, particularly animal studies of senolytic drugs capable of selectively destroying senescent cells, has convinced a great many people that this is a plausible near term goal.

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How Important is the Skin Microbiome in Skin Aging?

Changes in the gut microbiome have a role in aging, and the activities of microbial species (generation of beneficial metabolites, versus generation of harmful inflammation) may be as important as lifestyle choices such as exercise when it comes to the pace of aging.

Certainly there is good evidence for rejuvenation of the gut microbiome via fecal microbiota transplantation to improve health and extend life in short-lived laboratory species. Is the skin microbiome similarly important to the physical manifestations of skin aging?

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On the Aging Adaptive Immune System

An interesting fact about the adaptive immune system: the number of T cells in the body remains much the same across the entire lifespan, even after the supply of new T cells all but ceases in middle age.

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