Dear Future Centenarian,

Joe Polish sent the following message to his clients… and it confirms what I have been preaching for over a decade.

His timing could not have been more spot on. (More about that in a moment.)

Joe is also a life extensionist and his organization stresses the importance of taking care of your health to their business clients. Joe is the picture of health and practices what he preaches.

Here are some excerpts from his letter…

You will make more money and have a better life by learning how to eat well and exercise above almost anything else.

This is how you get your brain to work well.

If you take care of your brain and body, THAT will take you through life.

When you add being a Giver, and focusing on helping other people, on top of taking care of your brain and body, you can get almost anything you want in your Life.

There are millions of distracting things in the world trying to scare you, take you off course, and emotionally destabilize you.

Don’t let them.

Now for Joe’s timing…

I just put finishing touches on seven separate e-books, each a piece of the puzzle that could buy you more healthy time on this planet. That widens your window of opportunity to be alive when full body rejuvenation is more or less perfected.

The well-researched personal habit tips in these seven steps could deliver 10-20 extra vibrant years to you.

And the first two, eat well and exercise, are exactly what Joe said. Here are brief descriptions of Volumes 1 and 2 in the series. Volume 1 is for sale on Amazon, but you can download it for free.

I would VERY much appreciate it if you would then take a few moments to give it a good Amazon review HERE. All you have to do is scroll down to the bottom of the page.

Volume 2 should be posted there soon. You can download both at the links below, and I have attached both PDF files to this letter if that is easier for you.

Volume 1

What would you do with another 20 vibrant years?

Of all things under your control, deciding on what you eat and do not eat is the most powerful tool you own to determine how well and how long you will live. There are few topics as fraught with misinformation as nutrition. The first volume of the Maximum Longevity series clears up this mystery.

David Kekich, a pillar in the life extension community for over 25 years, screens the latest advances in this dynamic field to deliver you actionable advice on how to achieve maximum wellness, energy, and health while avoiding over 80% of the deadliest diseases.

Go HERE for the download.

Volume 2

Forget “No Pain – No Gain.”

Discover how exercising for healthy longevity can be fun in addition to all the life enhancing benefits it delivers. There is something here for everyone interested in extending your life while avoiding nursing homes and dependence on others.

From couch potatoes to trained athletes, if you want to look and feel your best, for years beyond your expected lifespan, you will find out how to thrive where most don’t even survive.

Go HERE for the download.

Don’t be fooled by how simple it is to slash your odds of getting seriously ill… and to increase your odds of far exceeding your projected life expectancy.

If you do nothing else this week, please read both. And feel free to share with your loved ones. Simply forward this letter to them.

The rest of the series should be posted soon.

More Life,
David Kekich



Weekly News

If We Could Efficiently Address the Causes of Aging, No-One Would Care About Social and Behavioral Factors in Aging

Aging is caused primarily by our biology, not by our choices. You can certainly cause yourself to age more rapidly by neglecting your health, but the only reason that we see any great level of concern regarding social and behavioral factors in aging is that rejuvenation therapies that have far larger beneficial results than exercise and diet are not yet in widespread use.

So people can today look at effect sizes of a year gained here and a year lost there via lifestyle choices and think that this merits further investigation and funding, as it is on a par with what has been achieved via the poor past approaches to treating age-related disease.

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Lamin B1 in the Age-Related Loss of Neural Stem Cell Activity

Neurogenesis is the creation and integration of new neurons into neural circuits, necessary for learning, and for the maintenance of functional brain tissue. Neural stem cells are responsible for providing a supply of new neurons, but, as is the case for stem cells throughout the body, their activity declines with age.

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Reporting on a Study of One with Flagellin Immunization to Adjust the Gut Microbiome

This post is a report on a self-experiment with flagellin immunization, tested as an approach to adjust the gut microbiome in a favorable direction. Flagellin is the protein that makes up bacterial flagellae, and it is hypothesized that there is a sizable overlap between populations of gut microbes that possess flagellae and populations of gut microbes that are harmful rather than helpful.

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The Role of Reactive Oxygen Species in Aging is Complex

Every compound and aspect of biology has a dose-response relationship of some sort. Wildly different outcomes should be expected at different levels of a drug, different degrees of expression of a protein, differing activity of a signaling pathway.

What is a beneficial therapy at one dose is a toxin at another. A great many toxic substances and ostensibly harmful processes that damage the mechanisms of a cell are in fact beneficial at low doses, thanks to the hormetic response.

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A Discussion of Epigenetic Reprogramming and Rejuvenation

Cell reprogramming can be achieved by gene therapies that express pluripotency genes – some or all of the Yamanaka factors.

It is akin to the process that takes place in the early stages of embryonic development, and which removes the mitochondrial dysfunction and epigenetic alterations found in old tissues. Although germline cells are already very well protected, this extra step is necessary in order for children to be born physiologically young.

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Physical Exercise and the Resilience of the Brain to Aging

Being active and fit slows the impact of aging on the brain. A diverse set of mechanisms are involved, and, as is often the case in these matters, it is far from clear as to which of these mechanisms are the most important.

Fitness helps to maintain the vascular system in a better shape, keep levels of chronic inflammation lower, causes mild stress that makes cells throughout the body undertake greater maintenance activities, ensures that the gut microbiome ages more slowly, better maintaining the production of metabolites that affect neurogenesis. And so forth – the list goes on.

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Pharmacology to Target the Mechanisms of Aging is a Going Concern

Traditional pharmacological drug development involves (a) identifying a protein or protein interaction of interest in the body, (b) screening the small molecule libraries for a compound that affects that target, and then (c) making a better version of that small molecule: more effective, less harmful.

That remains the bulk of the medical research and development industry, despite the proliferation of other approaches, including cell therapies, gene therapies, recombinant proteins, monoclonal antibodies, and so forth. There are goals that cannot be achieved by small molecules, and, as techniques improve and costs fall, gene therapies of various sorts will ultimately replace a great many small molecule therapies.

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Transcriptional Differences in Non-Coding RNA Between Fit and Sedentary Elderly People

Structured exercise programs cause sweeping beneficial changes in metabolism and the transcriptional landscape of cells in older individuals.

Health improves, mortality is reduced, numerous measures of the aging of muscle tissue slowed. Researchers here look at one small slice of this bigger picture, the activity of non-coding RNAs in muscle tissue.

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What is Known of the Interaction of Cancer Stem Cells and Tumor Associated Macrophages

Cancers subvert the immune system in order to survive, but also to accelerate their growth. Macrophages are a part of the innate immune system, and have roles in wound healing.

They become engaged by a tumor; tumor-associated macrophages assist in the rampant growth of tumor cells by supporting them in an analogous way to the support of regrowth in injured tissues. A cancer is, in many ways, the twisted reflection of regeneration.

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The SREBP Pathway is a Mechanism by which Cancers Subvert Regulatory T Cells

Cancers subvert the immune system in a variety of ways, such as in order to aid growth, or suppress the immune response normally triggered by the presence of cancerous cells. Regulatory T cells are involved in halting the immune response after it is has done its job, and in preventing autoimmunity, in which the immune system attacks the body.

This role is abused in cancerous tissue in order to protect the cancer from the immune system.

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A Mechanism by Which Exercise Strengthens Bone and Immune Function

Regular exercise is very beneficial for long-term health, generating sweeping changes in metabolism and improving tissue and organ function across the board.

Research suggests that present recommendations for the optimal amount of exercise are probably half or less of what they should be.

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Neurofilament Light Chain Levels in Blood Plasma as a Biomarker of Aging

The measurement of biological rather than chronological age is a goal for many research groups. Numerous approaches are under development, and the levels of a wide variety of compounds in the blood have been found to vary with advancing age.

The example here, neurofilament light chain, is just one of many. A robust biomarker of biological age, measuring the burden of many different forms of cell and tissue damage, as well as their downstream consequences, will likely be a combination of numerous different measures.

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Targeting the Mitochondrial Permeability Transition Pore to Restore Mitochondrial Function in Aging

There is an increased interest in the mitochondrial permeability transition pore as a target for interventions that might improve mitochondrial function in aging.

Mitochondria are the power plants of the cell, bacteria-like factories that package the chemical energy store molecule ATP via an energetic process of reactions. Mitochondria become dysfunction in aged tissues for reasons that include changes in their ability to divide and fuse together, and a faltering in the quality control mechanism of mitophagy. This loss of function is particularly important in the aging of energy-hungry tissues such as the muscles and brain.

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Elastrin Develops a Means to Break Down Calcification of Tissues

Calcification of tissues is one of the mechanisms by which stiffening occurs in the cardiovascular system, leading to a range of increasingly serious downstream consequences.

The evidence of recent years suggests that chronic inflammation and the harmful signaling of senescent cells are a major cause of cells in blood vessel walls inappropriately taking on osteoblast-like behavior, depositing calcium into the extracellular matrix as though they are building bone.

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Combining Cell Reprogramming and Scaffold Materials for Muscle Regrowth

A well established field of research is focused on the development of implantable scaffold materials to encourage regeneration of lost tissue, such as in the case of severe muscle injuries.

A wide variety of scaffold approaches incorporate signaling molecules and increasingly sophisticated small-scale structure, all intended to mimic aspects of the natural extracellular matrix, as well as other features. Use of a natural extracellular matrix is also an option, via decellularization of donor tissue. A great deal of innovation is taking place. As an example, researchers here combine a scaffolding approach with cell reprogramming to demonstrate muscle regrowth in an animal model.

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