Dear Future Centenarian,

Before we review the side effects I experienced, mostly from the general anesthesia for my spinal decompression, I’d like to point that I never regretted having the surgery. It was necessary and deemed a success by the surgeon.

In addition to improvement in my pain level the past 5 days, my scoliosis was instantly reversed by about 75%. Pain was the reason for the surgery… scoliosis reversal was a happy surprise.

My torso no longer leans to the side, and a huge bulge on my left flank corrected itself by 75% or so right after the surgery.

Over the past 10 years, it got progressively worse. In fact, my navel gradually shifted left, until it was at least 1.5” inches off center. It’s still off – but closer.

Otherwise, it’s been rough going since the March 31 procedure. Doctors suspected sepsis and pneumonia. It got so bad that I had to go to the emergency room on Friday by ambulance.

I tested negative for pneumonia last week, and they ruled out sepsis (big relief). I should get lab results on another possible infection any time now.

But I still have the same issues that landed me in the ER and expect to correct them after my labs are finished. Meanwhile, I’ll have to ride it out.

I don’t mean to turn a longevity newsletter into “It’s all about me” essays. What I do aim to do is drive home how important it is for you to avoid most of the life shortening diseases that could land YOU in an operating room.

I covered that last week too and the info at the end of this essay makes it easier for you.

Following are the side effects from last week’s letter. I deleted the narrative after each and added current status.

Chills – Still have them.

Sweating – I still have 24 hour cold sweats. Probably caused by an infection.

Persistent dry cough – Somewhat better. My primary physician thinks it’s caused by a sinus infection. He prescribed nasal sprays a few days ago.

Gas – Much improved.

Nausea – Very slight but no longer an issue.

Appetite – It’s getting better and I’m working to gain back the weight I lost.

Hiccups – No longer an issue.

Sore throat – Now normal.

Cramping – It got worse last week but it seems like I’m almost normal now.

Constipation – I thought it was better but is more complicated now.

Diarrhea – Replaced by that other troublesome bowel issue. I expect to resolve this soon.

Brain fog – Much better, but I still have lapses.

Pain – Nice improvement the past 5 days.

Infection – Once we identify exactly what it is… maybe we will by the time you read this… I should turn the corner quickly.

Let me repeat… I DO NOT WANT ANY OF THIS TO HAPPEN TO YOU.

You can lower your risk by 80% simply by reading my 7 e-book series – “Maximum Longevity.” As a bonus, you could add 10-20 healthy years to your life.

You can find them at https://www.amazon.com/s?k=kekich&i=stripbooks&ref=nb_sb_noss_1.

And as a subscriber, you can get them for FREE. Simply email me at hanno2033@gmail.com. I do ask that you give them good reviews which will allow me to reach more readers and save more lives.

More Life,
David Kekich

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Weekly News

A New Model Suggests a Higher Burden of Death Due to Particulate Air Pollution

Particulate air pollution is generally agreed upon to be harmful to long-term health, particularly from sources prevalent in poorer regions of the world such as the smoke from wood fires used for cooking.

Exposure to these airborne particles raises the burden of chronic inflammation, thus accelerating the onset and progression of all of the common age-related diseases, including cardiovascular disease and dementia, and increasing age-related mortality.

Read More https://www.fightaging.org/archives/2021/04/a-new-model-suggests-a-higher-burden-of-death-due-to-particulate-air-pollution/

Delivery of Recombinant Serum Albumin Extends Life Span in Old Mice

An interesting result is reported in today’s open access preprint paper. The authors find that the life span of mice is extended by 20% or so after treatment every few weeks with serum albumin, beginning in mid-life.

Read More https://www.fightaging.org/archives/2021/04/delivery-of-recombinant-serum-albumin-extends-life-span-in-old-mice/

A View of Early Modern Trends in Longevity Derived from Data on European Scholars

Upward trends in longevity started as least as early as the 16th century in some parts of the world, and earlier elsewhere.

Read More https://www.fightaging.org/archives/2021/04/a-view-of-early-modern-trends-in-longevity-derived-from-data-on-european-scholars/

Recent Thought on Alzheimer’s Disease as a Lifestyle Condition

The overwhelming majority of type 2 diabetes patients suffer their condition because they became significantly overweight. Being significantly overweight clearly produces the metabolic syndrome that leads to type 2 diabetes, and the more visceral fat tissue, the worse off you are.

Read More https://www.fightaging.org/archives/2021/04/recent-thought-on-alzheimers-disease-as-a-lifestyle-condition/

The Latest Data from the Interventions Testing Program: Nicotinamide Riboside has No Effect on Mouse Life Span

The Interventions Testing Program (ITP) at the National Institute on Aging runs very rigorous, costly life span studies in large numbers of mice, picking a few interventions to test each year.

The usual outcome is that a treatment with some interesting past results is found to have absolutely no effect on life span when run through the rigor of the ITP process.

Read More https://www.fightaging.org/archives/2021/04/the-latest-data-from-the-interventions-testing-program-nicotinamide-riboside-has-no-effect-on-mouse-life-span/

Measuring Gene Expression Changes in the Brain as a Result of Heart Failure

Heart failure causes harm to the brain by reducing the supply of blood, and thus the supply vital nutrients and oxygen, to brain cells. The precise details of how this leads to cognitive decline are yet to be fully mapped.

Read More https://www.fightaging.org/archives/2021/04/measuring-gene-expression-changes-in-the-brain-as-a-result-of-heart-failure/

A Feedback Loop Between Chronic Inflammation and Pressure Sensing Drives Osteoarthritis

Researchers here present an interesting view of how chronic inflammation affects cartilage tissue to cause the progression of osteoarthritis.

Read More https://www.fightaging.org/archives/2021/04/a-feedback-loop-between-chronic-inflammation-and-pressure-sensing-drives-osteoarthritis/

7.2% of All Deaths Worldwide are Attributable to Physical Inactivity

Humans evolved in an environment of physical exertion, and our biochemistry requires physical exertion in order to trigger mechanisms of cell maintenance and metabolic regulation.

Read More https://www.fightaging.org/archives/2021/04/7-2-of-all-deaths-worldwide-are-attributable-to-physical-inactivity/

Methionine Restriction Greatly Reduces Measures of Cognitive Decline in Mice

Researchers here applied three months of a methionine restricted diet to old mice, and found that it greatly reduced age-related cognitive decline, as measured in maze tests.

Read More https://www.fightaging.org/archives/2021/04/methionine-restriction-greatly-reduces-measures-of-cognitive-decline-in-mice/

Senescent T Cells Cause Changes in Fat Tissue that are Harmful to Long-Term Health

There is a much greater awareness in the scientific community of the importance of cellular senescence to aging.

Read More https://www.fightaging.org/archives/2021/04/senescent-t-cells-cause-changes-in-fat-tissue-that-are-harmful-to-long-term-health/

Regular Exercise Reduces Measures of Immunosenescence in Old Individuals

Regular exercise improves many aspects of health in later life. It reduces incidence of age-related disease and mortality risk by a significant degree.

Read More https://www.fightaging.org/archives/2021/04/regular-exercise-reduces-measures-of-immunosenescence-in-old-individuals/

A Non-Invasive Biomarker to Measure the Effectiveness of Senolytic Drugs

Researchers here note the discovery of a non-invasive biomarker that can measure the pace of destruction of senescent cells. This could be used to more rapidly quantify the effectiveness of potential senolytic treatments, those capable of destroying senescent cells, thus speeding up development of the next generation of senolytic drugs.

Read More https://www.fightaging.org/archives/2021/04/a-non-invasive-biomarker-to-measure-the-effectiveness-of-senolytic-drugs/

Better Diet and Regular Exercise Improve Cardiometabolic Health in Later Life

A sensible diet and adherence to a program of regular exercise have a meaningful effect on late life health, as illustrated by this epidemiological study.

Read More https://www.fightaging.org/archives/2021/04/better-diet-and-regular-exercise-improve-cardiometabolic-health-in-later-life/

Blood-Brain Barrier Dysfunction Predicts Progression of Cerebral Small Vessel Disease

Cerebral small vessel disease is characterized by the accumulation of small volumes of damaged tissue in the brain, the results of the rupture or blockage of tiny blood vessels.

Read More https://www.fightaging.org/archives/2021/04/blood-brain-barrier-dysfunction-predicts-progression-of-cerebral-small-vessel-disease/

Mesenchymal Stem Cell Derived Extracellular Vesicles Slow the Accelerated Aging of Progeroid Mice

Researchers here show that, in a progeroid mouse model that exhibits high levels of cellular senescence and accelerated manifestations of aging, delivering extracellular vesicles harvested from mesenchymal stem cells has much the same effect as delivering the cells as a therapy.

Read More https://www.fightaging.org/archives/2021/04/mesenchymal-stem-cell-derived-extracellular-vesicles-slow-the-accelerated-aging-of-progeroid-mice/