International Scientific Conference I - June, 2000
June 2000 Scientific Conference
On June 24th and 25th, 2000, Maximum Life Foundation sponsored its first international anti-aging medicine scientific conference at the Manhattan Beach Marriott in Manhattan Beach, California.
Its purpose was to brainstorm ideas that could lead to breakthroughs in anti-aging medicine.
In this inaugural conference, the participants were asked to provide Maximum Life Foundation's staff with a framework to begin assessing the current state of gerontological research.
Stephen Coles, MD, PhD
Aubrey de Grey, PhD
|President, Aeiveos Corp
Cofounder, L.A. Gerontology Research Group
Research Associate, Cambridge University, Dept. of Genetics
|Gregory Fahy, PhD
|VP & Director of R & D, 21st Century Medicine
Research Fellow, Institute for Molecular Manufacturing; Research Scientist, Zyvex Inc.
|Chris Heward, PhD
||Director, Research and Development, The Kronos Group; Senior Research Fellow, UCLA Program on Medicine, Technology and Society
|Michal Preminger, PhD
Michael Rose, PhD
|VP Drug Discovery, Compugen Inc.
Professor, Evolutionary Biology of Aging, Evolutionary Genetics, University of California, Irvine
|George Roth, PhD
Jeff Seilhamer, PhD
Greg Stock, PhD
|President Gerotech, Inc.; Senior Guest Scientist, NIA
VP, Exploratory Biology, Incyte Genomics, Inc.
Director, UCLA Program on Medicine, Technology and Society
|Bob Swanson, PhD
Rick Weindruch, PhD
|VP, Global Systems, Concurrent Technologies Corp
Professor, Medical School, University of Wisconsin-Madison
||President, Maximum Life Foundation
||Vice President, Maximum Life Foundation
|Secretary, Maximum Life Foundation
Operations Manager, Maximum Life Foundation
The following is a breakdown of the ideas discussed at the Conference.
General Thoughts in the Field
- Prioritize Interventions
- Aging Viewed as a Thermodynamic Process
- Biomarkers - Metrics of Aging
- Identify Environmental Factors
- Definitively Proving or Disproving Theories of Aging - Slaughtering Sacred Cows
- Nuclear DNA Mutations/ Telomeres - polymerase, methylase, telomere control
- Mitochondrial DNA Mutations - dodgy gamma polymerase
- Lipofuscin - Vit. E deficiency?
- Extracellular/Vascular Junk (plaques)
- Devise Methods to Take Advantage of the Emerging Technologies
- Brute Force Technologies:
- Computational Power - Bioinformatics
- Lab on a Chip Tech
- Proteomics - Protein-Protein Interactions
Social Engineering - Swaying Public Opinion
- Sell the Psychology Before Selling the Technology
- Unite Scientific and Lay Communities
- Promote the View that Aging is a Genetic Disease
- Killer Application To Get Public Behind the Science
Genomics - What Genes are Involved in Aging?
- Monitor Tissue Specific mRNA Expression Levels to Determine Which Genes are Affected by CR Regimens. Lifespan Genetics Proposes to Have this Information in Two to Three Years.
- Identify Longevity Assurance Genes and Their Regulation
Proposed Genomic Information Targets
- Long and Short Lived Opossums
- Immortal Organisms - Hydras, Sea Anemone
- Centenarians/Long Lived Families
- Find Agenes in Species with Characterized Genomes and Look for Homologues in Uncharacterized Species
- C. elegans
- Drosophila - Incyte Predicts Fly Chip Over the Next Few Months
- SNP Chips - Observe Allelic Polymorphisms within a Population of Species
- Use Transgenic (Knock in/ Knock out) Approaches to Validate the Causality of Genetic Findings.
- Studies on Regulation Glucagon/Insulin, Renin/Angiotensin/Aldosterone, and Sex Hormone Axes Changes with Aging Will Lead to Understanding of Global Genetic Regulation.
- CIStem Molecular Corp.- Regulomics -Rapidly Elucidate Cis Sequences and Trans Factors Involved in Any Genetic Circuit
- Gerotech - Study Physiology of CR, Searching for CR Mimetics
- Up-Regulation of Heat Shock Proteins and Anti-Oxidant Enzymes to Retard Aging
- Hormone Therapy - Quality of Life Kronos Group Hormone Treatment Battery Single Gene Drug Targets
- Micronutrients tested by Kronos
- Alpha Lipoic Acid
- Find Genes that Maintain Stem Cells as Stem Cells
- Identify Factors for Differentiation and De-differentiation (Geron/Celera Collaboration)
- Find Out Cause of Totipotency in Egg/Sperm Union (Spermatagonia/Oogonia)
- Adult Mesenchymal Cells that Act as Stem Cells -Possibility of Manipulation?
- Tissue Engineering and Complex Structure Regeneration
Things That Need to Be Developed
- Incyte Fly Chips, SNP Chips Humans 2 yrs, Mouse Chips?
- Primate - Rhesus, Chimpanzee
- Aging Genome Library (ala Cancer Genome Library)
- Mortality Rate Databases (Control for Human Experiments)
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- Funding - $1.5 Million, Lab Equipment
- $400,000 Chip Building Robot
- Possible Funding By NSF
- Space - 4000 - 6000 sq ft for 8-16 Technicians
- Database Programmers
- Secured Channel Email/Phone System
- Explore possibility of using space in P4 labs being build around the country
- Facility Capabilities
- Genetic Model Comparisons
- Chip Technology
- CR Mimetic Studies
- Explore University Affiliations for Basic Science Research
- Patent, Properties Problems
- Caltech Incubator Space
- Cyclical Contracting With Kronos Group
- Contracting With CTC, Incyte, Compugen