Longevity News Digest
How to Increase Your Odds of Everything Good by 10X
Dear Future Centenarian,Â
Not just increasing your odds for youthful longevity¦ but for EVERYTHING.
Most of my subscribers want more healthy years “ way more. So they are proactive. Some others, like most of the world, react like they have gotten old by surprise¦ or they got diagnosed with something bad by surprise.
A common thread that we all share though is “ we want MORE. We want answers. That™s what MaxLife is all about “ digging up¦ or even creating answers. Our efforts over the past few years were on creating the answers that don™t exist yet. 90% of our efforts.
And I™m glad to report that we have created two amazing breakthroughs already. One will be revealed before the end of the year.
So how did we do what others didn™t, or couldn™t? The easy answer is œtechnology. But it goes way deeper than that.
I took a page out of Dan Sullivan™s playbook and applied it to the complex task of how to add magnificent years to anyone™s life who will listen¦ in spite of themselves.
As it turns out, I care more about most people than they usually care about themselves. I™ll bet you™ve experienced that yourself. Haven™t you ever tried helping someone with easy to follow advice when you see them hurting themselves, even destroying themselves¦ only to have them ignore you?
It™s heartbreaking, isn™t it? Especially if they are loved ones.
Hardly anyone is willing to put forth the effort. Then, once disaster strikes, they™ll bulldoze you and anyone else in their path to find a cure if they have to.
Someday, it™ll be easy. The technologies we and other motivated individuals support will obsolete aging and diseases once and for all. But until that someday, we™ll have to be proactive if we want to live until then.
The page I mentioned out of Dan™s playbook? His 10X strategy.
It™s real simple “ and counter to how almost everyone on the planet thinks.
When most of us forge plans, we start with the past. A problem that popped up before this very instant for example. Of course, since time does not stand still, everything but current thoughts took place in the past. But here™s where it gets interesting:
When we strategize on how to solve these problems, on how to plan for an outcome (everything from something as simple and mundane as tonight™s dinner, to the most important business or personal goal you want to achieve), what do you usually do? You draw on past experiences to build on.
But this is LIMITING and CONSTRAINING.
Sure, past experience is valuable if you learn from it, and you need to do that to keep improving. However, you will only improve incrementally¦ maybe by a factor of two or so¦ if you™re lucky. And it™s tedious.
Instead, what if you did this:
Project yourself into your future, and set a big, bodacious, and even frightening goal.
This forces you to stretch. It forces creativity.
It™s the way to improve your results by a factor of ten or so.
And do you want to know major side benefits?
- It™s actually easier.
- It energizes you instead of draining you.
In order to make something big happen in your life, start with your future to free up your present from your past as much as possible.
My goal “ reverse aging by 2033. Not going to do it with backwards thinking.
Your outcome? Whatever you want. But for a start, how about staying youthful and well until rejuvenating technologies hit the scene?
Latest Headlines from Fight Aging!
Growing a New Thymus From Engineered Cells - Monday, August 25, 2014
The thymus is vital to generation of new immune cells, and the fact that it atrophies early in life, turning a river of new cells into a trickle, is one of the factors placing an effective cap on the adult immune cell population.
In part because of this limit in later life competent immune cells capable of dealing with new threats are crowded out by other immune cell types. Solutions to this issue include restoration of a larger supply of new cells by restoring the thymus or targeted destruction of the excess cells to free up space and spur the body to generate replacement immune cells that are capable of doing their jobs.
Earlier this year researchers published a demonstration of a short cut to rejuvenate the aged thymus simply by manipulating levels of FOXN1 to boost the population of certain important progenitor cells responsible for maintaining the thymus.
It is rare to find such short cuts in tissue engineering, and this one most likely only exists for the thymus because of its unusual early decline in adults - a course very different from most organs, and which may have a comparatively simple set of triggers. Here the same research group shows off the next stage in their work, which is the generation of a complete new thymus in vivo by much the same set of mechanisms.
Inhibiting P38 MAPK Restores Proliferation in Senescent T Cells - Monday, August 25, 2014
Senescent non-dividing cells of all types accumulate in various tissues. This is probably an adaptation that acts to suppress cancer risk, but these cells secrete damaging compounds that degrade nearby tissue function and cause surrounding cells to also tend towards senescence.
The most straightforward approach to removing this contribution to degenerative aging is some form of targeted destruction of senescent cells, perhaps via adaptation of any one of the numerous cell killer technologies under development in the cancer research community.
In recent years some progress has been made in another direction, that of reversing the senescent state of cells. Ultimately the research community will be able to reprogram any cell into any desired state, but that lies a way into the future yet.
Reversing senescence will undoubtedly prove complicated and tissue-specific, and there is the open question of whether this will increase cancer risk. Here is an example of one small step on this road, but note that it is only restoring the ability of one type of senescent cell to divide once more. It may or may not be adequately addressing the other undesirable behaviors of the cells, and may or may not turn out to be the best approach.
Everything Looks the Same in the Distance - Tuesday, August 26, 2014
One of the challenges we face in directing fund and attention to the most promising research into human longevity, rather than efforts that are doomed from the start to achieve no meaningful near term gains, is that from the distance of unfamiliarity everything looks the same.
The average journalist or person in the street can't tell the difference between SENS rejuvenation research, metabolic alterations with a poor chance of slightly slowing aging after the Longevity Dividend model, research into genetics of longevity and personalized medicine, and opportunists who cloak their old-fashioned health businesses with the mere appearance of modern longevity science. From the perspective of people at a distance it all looks the same, equally valid. Which is far from being the case.
This article is an example of the phenomenon, in which it is a matter of accident and publicity as to whom the author discusses, rather than whether or not their efforts are relevant or effective. Thus what is intended to be a discussion of Silicon Valley initiatives targeting aging and longevity manages to omit the SENS Research Foundation, despite the organization being headquartered there, and spends many of its words on the next generation of self-deluding snake oil salespeople, pushing the quantified self rather than pills this time around.
Apolipoprotein B Variants and Exceptional Human Longevity - Tuesday, August 26, 2014
Studies of human longevity-associated genes produce results that tend to be hard to replicate. The effects are individually tiny and vary widely between study populations, indicating a complex web of influences.
Only a few genes stand out as having small and consistent rather than tiny and varying associations with longevity, such as APOE variants involved in the operation of cholesterol metabolism among other things. So on the one hand expect the results of this study to be hard to replicate, especially given the small sample size, but on the other hand it is somewhat connected to APOE so we shall see.
Advocating Arterial Destiffening to Treat Cardiovascular Disease - Wednesday, August 27, 2014
It is always good to see more scientists come around to the SENS viewpoint of damage repair as the best treatment for age-related disease.
Addressing root causes is a much better approach than the current prevalent paradigm of trying to adapt failing biological systems to work less poorly when damaged, while failing to make a dent in the damage itself. Tackling the root causes should be much more cost-effective and simply much more effective overall, and in many cases the root causes for specific age-related conditions are known rather than merely surmised.
Identifying Tissue Weakness Before Injury - Wednesday, August 27, 2014
This is an interesting technology demonstration that suggests an obvious pairing with regenerative treatments based on the use of stem cells or similar means to spur tissue repair.
With regular scans it might be possible to preempt many instances of muscle and bone injury caused by use and stress, preventing them from ever developing by repairing tissue weak spots before they develop into injuries.
The Cost of a Sedentary Lifestyle to Muscle and Bone - Thursday, August 28, 2014
A mountain of evidence exists to demonstrate that being sedentary will lead to greater ill health and a shorter life expectancy. As we inch closer towards the implementation of rejuvenation treatments at some uncertain point in the decades ahead, every year of health and life gained counts, raising the odds of living long enough to benefit from proposed ways to repair the damage of aging.
A Potential Source of Cardiac Stem Cells - Thursday, August 28, 2014
Many research groups in the stem cell field are engaged in a search for sources of useful tissue-specific cells in the body, developing means of identification and isolation. This runs in parallel with efforts to reprogram more easily obtained cells, such as from skin samples, into a range of different types for therapy and research.
Both approaches add value in the near term, expanding the range of tissues in which regeneration might be greatly enhanced. The heart is of particular interest as it normally has little capacity for repair, and is of course the cause of a great many fatal problems as we age. Here is an example of progress in identifying existing cell populations that support heart tissue.
Nasal Cartilage Cells Can Replace Joint Cartilage - Friday, August 29, 2014
Cartilage regeneration and tissue engineering has proven more difficult than initially expected. It is a tissue with a deceptively complex structure, in which important mechanical properties necessary to its load-bearing role are derived from the details of that structure.
Simply culturing cartilage cells is far from enough to produce a useful end result, and researchers have only recently made inroads into producing tissue engineered cartilage that is somewhat like the real thing. In this work a novel approach is taken to produce grafts for injured joint cartilage.
The Prospects for Therapies and Enhancements via Magnetic Stimulation of the Brain - Friday, August 29, 2014
Transcranial magnetic stimulation (TMS) is a fascinating field of study in which it is clearly possible to affect the brain, but researchers are still in the comparatively early stages of finding out how to reliably produce and measure useful end results.
The research noted here is an example of one of the more positive findings, a way to enhance memory function. It doesn't address underlying causes of dysfunction in aging, unfortunately, rather being a possible methodology to compensate somewhat for losses. This isn't the preferred direction for medicine if we seek true prevention and cure of age-related loss of function, but as for many such things, one has to ask "why not see whether or not this can be applied all the time, for everyone?"
DISCLAIMER:Â News summaries are reported by third parties, and there is no guarantee of accuracy. This newsletter is not meant to substitute for your personal due diligence and is not to be taken as medical advice. For originating report, please see www.fightaging.org/
David A. Kekich
Maximum Life Foundation
"Where Biotech, Infotech and Nanotech
Â Â Â Â Meet to Reverse Aging by 2033"