Longevity News Digest
Extreme Longevity Tide is Turning
Dear Future Centenarian,
The Treasurer of Australia recently received widespread attention with the statement: "It's kind of remarkable that somewhere in the world today, it's highly probable that a child has been born who will live to be 150."
The Dean of Medicine at the University of New South Wales described Mr. Hockey's claim as a "reasonable assumption".
I think they're waaay understating. But at least it's a start. Even conservative politicians and academics are starting to get it.
Following are some comments that Reason at www.FightAging.org made:
The most significant consideration favoring lifespans of 150 in the near future term, then, is the fact that there is now a lot of interest in life extension research, both within academia and from well-funded corporations.
One research direction companies are likely to explore involves incorporating nanotechnologies into our cells. Many gerontologists believe that aging consists solely of a small number of cellular changes, which are potentially preventable and reversible. Once we develop technologies capable of preventing and reversing these changes, we can prevent and reverse aging.
Aubrey de Grey pointed out more than ten years ago in this environment of progress in biotechnology, there is little difference between adding a few decades and adding a few centuries.
A very binary divide lies ahead of us: either you live long enough to see medical science start to add additional years of life faster than aging can take it away, or you don't.
If you do, then your life span is thereafter only bounded by accidents, which given present mortality rates means you will probably live for a thousand years or so, in excellent health and with a youthful physique periodically repaired by ever more advanced therapies.
Science must be accompanied by advocacy, as at the large scale the only research to receive significant funding is that with widespread public support.
People support research on well-known diseases that are caused by aging, but at the same oppose work on greater longevity or eliminating aging, and yet are fearful and saddened by the costs of growing old and that deaths and suffering of those around them.
There is a steady evaporation of skepticism with regard to radical life extension, accelerating of late with the advent of several large and public initiatives in aging research.
One reason is, we're seeing more and more breakthroughs like this:
A research team from The Scripps Research Institute (TSRI), Mayo Clinic and other institutions has identified a new class of drugs that in animal models dramatically slows the aging processÐ²Ð‚"alleviating symptoms of frailty, improving cardiac function and extending a healthy lifespan.
And then when you see more smart money like this chasing longevity, it has to be encouraging:
"If you ask me today, is it possible to live to be 500? The answer is yes," The president and managing partner of Google Ventures Bill Maris says one January afternoon in Mountain View, California.
Both of these announcements are only a week old.
But don't get complacent. We have a long way to go before we can relax. We all need to raise more money as well as keep ourselves in the best shape possible.
Latest Headlines from Fight Aging!
Surveying Present Well-Known Initiatives in Longevity Science - Monday, March 9, 2015
One of the frustrating and probably incurable aspects of the popular press is that when a journalist reviews a field of work, he or she tends to paint every initiative as equal.
So when it comes to efforts to extend human life span, no distinction is made between projects that have a good chance of achieving radical life extension or rejuvenation and those that can at best produce a slight slowing of aging, or those that are practical and supported by the present state of scientific knowledge versus highly speculative goals that may not be possible to achieve for a lifetime yet.
To the journalist, these are all the same thing. It is something to think about whenever you read an article on an area of research or business with which you have no familiarity. You might not be learning as much as you think you are.
Read More https://www.fightaging.org/archives/2015/03/surveying-present-well-known-initiatives-in-longevity-science.php
The 2015 Alcor Conference Will Be Held in October - Monday, March 9, 2015
The cryonics industry conferences hosted by Alcor take place every three years. The last was in 2012, and if you take a look at the Alcor YouTube channel you'll find videos from the event.
These conferences are well attended by scientists in various fields, and the presentations are always interesting. The next conference in the series will be held later this year: the date is October 9th and the place is Scottsdale, Arizona.
This is a MUST attend event if you are serious about extreme life extension.
Discussing SKN-1 and the Extracellular Matrix in Aging - Tuesday, March 10, 2015
Here is a brief look at one small slice of research efforts focused on aging as it pertains to the extracellular matrix, the intricate structure of proteins that surrounds and supports cells.
The arrangement of extracellular matrix proteins determines the mechanical properties of a given tissue, such as elasticity or ability to bear load.
Read More https://www.fightaging.org/archives/2015/03/discussing-skn-1-and-the-extracellular-matrix-in-aging.php
Considering an Autoimmune Component to Alzheimer's Disease - Tuesday, March 10, 2015
The present consensus on Alzheimer's disease focuses on the accumulation of misfolded proteins into amyloid plaques as the crucial mechanism, and thus clearing amyloid is a major research focus.
Turning this focus into working therapies is taking far longer than expected, however, with numerous disappointing outcomes along the way so far. This state of affairs leads to a research environment in which other theories and approaches are multiplying, in search of better results. The example noted below is one of a great many initiatives that incorporate a quite different way of looking at the mechanisms of Alzheimer's disease.
Read More https://www.fightaging.org/archives/2015/03/considering-an-autoimmune-component-to-alzheimers-disease.php
Theorizing on H3.3 and Heterochromin in Aging - Wednesday, March 11, 2015
There are very many speculative theories on mechanisms of aging that await studies to prove or disprove their effects, as well as to demonstrate whether or not those effects are significant over a human life span. Here is one of them.
Read More https://www.fightaging.org/archives/2015/03/theorizing-on-h33-and-heterochromin-in-aging.php
Assessing Proteostatic Mechanisms in Long-Lived Mice - Wednesday, March 11, 2015
Proteostasis is the continued normal balance of protein levels and uses in cells. Aging and age-related disease by definition involve loss of proteostasis, such as through cellular damage and reactions to that damage.
A wide array of mechanisms work to maintain proteostasis, and the list should probably include near all of those involved in protein production, folding, and recycling. There are far more researchers focused on this aspect of aging than on damage repair after the SENS model, in which it is argued that we should focus on fixing underlying damage, at which point proteostasis mechanisms should be free to restore the normal balance of cellular operations.
Read More https://www.fightaging.org/archives/2015/03/assessing-proteostatic-mechanisms-in-long-lived-mice.php
Ultrasound Treatment for Amyloid in Alzheimer's Disease - Thursday, March 12, 2015
Researchers are investigating the use of ultrasound to reduce levels of harmful amyloid in the brain. At this point it is showing benefits in mice, but there is a way to go yet before there can be any certainty that this strategy can also work in humans.
Read More https://www.fightaging.org/archives/2015/03/ultrasound-treatment-for-amyloid-in-alzheimers-disease.php
A Proof of Concept for Repair of the Cerebral Cortex - Thursday, March 12, 2015
Regenerative medicine for the brain that enables periodic repair in situ is essential to the future of human longevity.
This is the only tissue in the body that cannot be outright replaced as a last resort, as its structure defines the data of the mind. Scientists are making some progress towards this goal, applying the tools developed in stem cell research in an increasingly refined way.
Read More https://www.fightaging.org/archives/2015/03/a-proof-of-concept-for-repair-of-the-cerebral-cortex.php
Looking Into Ways to Prevent Heart Calcification - Friday, March 13, 2015
Many elastic tissues harden with age in part due to calcification, an increased deposition of calcium between cells.
In the cardiovascular system this is eventually fatal, as elasticity in blood vessels and the heart are essential to proper function. The usual focus for discussion here is the stiffening of blood vessel walls through this and other mechanisms, causing hypertension and all its attendant consequences, but heart tissue also stiffens and calcifies.
Read More https://www.fightaging.org/archives/2015/03/looking-into-ways-to-prevent-heart-calcification.php
Overthinking Radical Life Extension - Friday, March 13, 2015
Some people spent a fair amount of time debating philosophical points on what it would be like to live for centuries or longer, a prospect that will become an actual possibility before the end of the century, enabled by the development of rejuvenation biotechnologies.
There is nothing wrong with that as a hobby, but the most disconnected, ridiculous arguments against a long life span have a way of finding their way back into discussions over today's funding for aging research.
Even the polemics in favor of radical life extension drift away into points that have little to do with day to day experiences of life, such as this one in which the author considers that aging into different opinions and ideals a century from now is actually undesirable and a viable argument in favor of dying instead.
Yet that prospect is hardly terrible; we are all living with it comfortably already, after all. No-one really expects to be exactly the same person twenty years from now, let alone hundreds were they available. Life is change and motion. The best argument for radical life extension via the medical control of degenerative aging is the simple one: that today we'd like to be alive and active tomorrow, and that was the state of things in all of our past days.
Read More https://www.fightaging.org/archives/2015/03/overthinking-radical-life-extension.php
DISCLAIMER: News summaries are reported by third parties, and there is no guarantee of accuracy. This newsletter is not meant to substitute for your personal due diligence and is not to be taken as medical advice. For originating report, please see www.fightaging.org/
David A. Kekich
Maximum Life Foundation
"Where Biotech, Infotech and Nanotech
Meet to Reverse Aging by 2033"