Longevity News Digest
3 Good Reasons to Live Longer
Dear Future Centenarian,Â
Last week I wrote about an absolutely amazing conference where I had the opportunity to speak about extreme longevity. I shared the stage with Arianna Huffington (see photo), Kevin Harrington, Daymond John and other luminaries.
Joe Polish pulled off the event of the year. More info at http://geniusnetwork.com.
Although the educational conference centered on entrepreneurship and marketing with speakers and attendees representing a wide variety of industries, the wellness field was the most heavily represented. Brian Kurtz who runs Boardroom, Inc is one example. Fitness queens such as Kathy Smith and JJ Virgin were there, and Dr. Daniel Amen presented, among others.
There was enough energy in that room to launch a rocket. Virtually everyone I met had such a zest for life that I just had to share it with you.
Don™t forget, this was a business/marketing conference. But most would be surprised at what makes a successful businessperson. It™s the same as what makes any person œsuccessful. Dan Sullivan, Strategic Coach founder builds œcharacter as well as teaching success strategies to his thousands of clients.
In fact, before you even think about success in business, Dan teaches you to be an accomplished friend, spouse, parent and basically a well-grounded well-integrated person. He is arguably the top ranked business and personal coach in the country.
So what did he talk about?
How to build successful relationships. How to reach and maintain your peak energy levels. How to grow your confidence. Why you should set 25 year goals¦ regardless of your age. How to appreciate and absolutely¦ LOVE life. He even revealed an easy way to multiply your desired outcomes (whatever they may be) by TEN TIMES.
And Dan was just one example. Dean Graziosi, who has been on TV every day for 13 years running, and who is the top current real estate investor guru, didn™t preach marketing or give any real estate tips. No. He talked about being a good husband and father.
In fact, these were common themes that were weaved throughout the conference. I didn™t meet one person there who did not have a specific purpose of life. They were long term thinkers. And just like you and me, they face their share of problems Like us, they experience heartbreaks.
But they bounce back. They see problems as opportunities. Most of them find something good in every pitfall. And what does this kind of mindset lead to?
Happiness. A reason and a strong will to live healthfully¦ and for a very looong time.
It™s not about the money. Most are prosperous. But money was a byproduct of their attitudes.
Joe Polish has been a Dan Sullivan student for about 17 years. Long ago, when he was telling me how amazing Dan™s program is, I asked him how much more income he made as a result. Joe does extremely well, but he looked at me like I was nuts. It wasn™t about earning more (although that happened too), it was all about self-development and self-worth.
As a subscriber, you are already future focused and motivated to improve. But go to http://10xtalk.com for a wealth of the best free info on the planet to stick your future in overdrive.
When I met Joe, he had no interest in longevity pursuits. Now he™s an avid life extensionist. I think it may have something to do with how much he grew as a person.
Self-esteem is critical if you want to be happy in the long term. And without happiness, living long may not be appealing.
I™m here to tell you, self-esteem isn™t something that is handed to you. It™s earned. It™s something you LEARN to build. Anyone can do it. Enduring happiness is the reward. If you want to learn more, read The 6 Pillars of Self Esteem by Nathaniel Brenden.
So here are your three good reasons to live longer:
- Open-ended Happiness
- Open-ended Opportunities
- Open-ended Love
P.S. I™s never too late to start. One of the speakers, in his mid-80™s, often puts in 14 hour days because of his passion for what he does. He keeps looking forward¦ NOT BACK.
P.P.S. Go to Amazon and devour at least ONE of Dan Sullivan™s books. Don™t worry¦ although power packed¦ they are extremely reader friendly.O And don™t forget to check out http://10xtalk.com and http://geniusnetwork.com.
Latest Headlines from Fight Aging!
We Justify What We Have No Choice In, To Our Detriment - Monday, August 18, 2014
People are good at building a belief that whatever cannot be changed in life is in fact a good situation. It is a lie, but it helps keep us sane in the face of miserable situations that we can do nothing about.
So while matters are improving with the advance of technology, the world remains packed wall to wall with pain and suffering, and with people who tell us that it is all good.
The pain and suffering of aging is the focus here at Fight Aging!, as it is the greatest cause of death and disease. Even here where the cost is so clear and so high positive change driven by progress in medical science is resisted by those who tell us that aging, a terrible degenerative condition that ends in death, is in fact a good thing.
Death is Wrong, Free PDF Version - Monday, August 18, 2014
Fresh from the success of a fundraiser to distribute copies of the children's book Death is Wrong, the PDF version is now freely available.
Grassroots advocacy for longevity science is made up of many such small projects, all of which are collectively necessary as a foundation for attracting greater support from more conservative institutions and high net worth individuals. Large donations only reliably arrive for fields in which public support is active and involved in this way.
Incremental Progress Towards Xenotransplantation - Tuesday, August 19, 2014
In between today and a future in which cell therapies are advanced enough to repair organs in situ a range of sophisticated transplant treatments will emerge to address organ failure.
Among the present contenders are decellularization of donor organs, artificial organs of various types, including bioprinted tissues, and xenotransplantation, the use of animal organs. The latter is moving towards practicality, step by step.
An Example of a Targeted Viral Cancer Therapy - Tuesday, August 19, 2014
The present standards for cancer treatment are poorly targeted in comparison to prototype work taking place in the labs and clinical trials.
Chemotherapy, radiotherapy, and the like have a detrimental impact on the rest of the body, and their effectiveness is limited by the degree to which they hurt the patient in the process of impacting cancer cells. Their days are numbered, however. A broad range of next generation targeted treatments have been demonstrated in recent years, with few side-effects because they affect only cancer cells and their nearest neighbors. A number of these therapies use existing biological systems as a means of targeting cancer cells, such as viruses.
Elite Athletes Live Longer - Wednesday, August 20, 2014
It remains an open question as to why top-level athletes live notably longer than the rest of us. The point of interest is to what degree the longevity difference is produced by exercise and training versus a population bias among successful athletes to more robust individuals who would live longer regardless of their profession. That's hard to answer at this point, and is a part of broader research regarding exercise, in that while moderate regular exercise is clearly beneficial, it is unknown as to whether anything more than merely moderate regular exercise is more beneficial over the long term.
Mapping Blood Vessel Elasticity in the Brain - Wednesday, August 20, 2014
Loss of elasticity in blood vessels occurs for a number of reasons, including the rising level of persistent cross-links that glue together important structural proteins, effects of chronic inflammation on mechanisms needed for blood vessel elasticity, and so forth. This form of structural failure has material consequences, raising the risk of life-threatening events such as stroke.
Exercise has been shown to slow the progression of blood vessel stiffening, and here a new technique for assessing blood vessel stiffness in the brain adds more data in support of that view. More importantly, this sort of technology will be very useful as a means of rapidly assessing the effectiveness of near future rejuvenation treatments, such as means to break glucosepane cross-links presently funded by the SENS Research Foundation.
Human Trials of Young Blood Transfused into Old Individuals - Thursday, August 21, 2014
Studies of parabiosis, in which a young and an old mouse have their blood systems joined, show that altering the balance of circulating proteins in old tissue can restore stem cells to action and revert a range of measures that change with age.
It is thought that frequent blood transfusions should capture at least some of this outcome, although it is unclear as to the degree to which the relevant proteins are short-lived in circulation, and transfusions are really just a stand-in for some yet to be established but more effective way of directly altering levels of the proteins of interest.
Stem cells decline and protein levels change as a reaction to rising levels of cellular damage, or at least that is the dominant view of aging as a process in the research community. In the case of stem cells this may be an evolved mechanism to suppress cancer risk, a balance between death by failing tissue maintenance versus death due to damaged cells running amok.
Thus there is some concern that crude changes intended to bring stem cells back into a youthful mode of activity will produce high rates of cancer, but it is entirely possible that this can be avoided while still retaining benefits. First generation stem cell treatments came attached to much the same concern, and where that concern was professionally addressed these therapies are clearly producing meaningful benefits in older people.
Media Babble on Greatly Extended Human Longevity is Drifting in a Positive Direction - Thursday, August 21, 2014
Radical life extension is the now somewhat dated term for the process of adding decades and then centuries to healthy life spans through near future rejuvenation therapies. The media has a quota system, I think, for turning out articles on this topic that are little better than babble.
A stream of consciousness is committed to the page and sent forth into the world. In past years this typically consisted entirely of knee-jerk objections and assertions that death by aging was a wonderful thing: that we live in the best of all worlds in which we are privileged to suffer and die to a schedule not our own, and besides the whole idea of living longer is impossible, as any sensible individual should see, and now let us stop dwelling upon fantasies of a world in which medicine improves and get back to something important, such as the latest celebrity gossip.
It is hopefully not just an illusion in my eyes, but I do believe I see some drift in a positive direction in the babble of late. Babble it may be, but it is still a signal of sorts. There is more of an acceptance of radical life extension as an inevitability, and something of a balancing of views.
The same old knee-jerk objections remain in force, but there are also wistful glances at the possibility of a life that is longer and better in all aspects. The times are changing, and the average media figure bends with the wind when it comes to any field in which large and very public investments are now happening. Take this piece from NPR, for example.
Supporting Evidence for Mitochondrial Transfer as Therapy - Friday, August 22, 2014
Bacteria-like mitochondria are the cell's power plants, and they become damaged with age. This damage spirals out to create a small but significant population of cells that export harmful reactive compounds into surrounding tissues and the circulatory system, contributing to a range of age-related conditions.
One possible approach to address this issue involves destroying existing damaged mitochondria and replacing them with undamaged versions. Simply introducing new undamaged mitochondria is an easier proposition but probably not sufficient, as the damaged versions overtake cells because they have an advantage in replication: diluting their numbers won't last very long.
Here researchers provide more evidence to show that simply introducing new mitochondria into a tissue environment is probably sufficient to see them taken up into cells and used. This is great news for work on inherited genetic mitochondrial disorders, where supplying new unmutated mitochondria should be a cure, but it is only a part of any potential treatment for the mitochondrial damage of aging based on mitochondrial replacement.
Cryopreservation at Alcor - Friday, August 22, 2014
Cryonics is the process of vitrifying the body and brain at death, preserving as much of the fine tissue structure as possible to enable the possibility of future restoration to life.
There's no fundamental barrier to achieving that revival other than the fact that the necessary technology doesn't yet exist, and subject to the continuation of storage facilities the vitrified cryopreservees can wait for that time to arrive. A small cryonics industry has existed for some four decades now, with the most established non-profit groups being Alcor and the Cryonics Institute in the US. Several hundred people are presently preserved. It is an undertaking with an unknown timeline and chance of success, but these are the best odds offered to those who will age to death prior to the development of rejuvenation treatments.
Like most popular press articles on cryonics, the piece quoted below confuses low-temperature vitrification with freezing. They are in fact two very different things with very different outcomes on tissue viability: vitrification minimizes ice crystal formation, for example, which is the cause of much of the damage to frozen tissues.
DISCLAIMER:Â News summaries are reported by third parties, and there is no guarantee of accuracy. This newsletter is not meant to substitute for your personal due diligence and is not to be taken as medical advice. For originating report, please see www.fightaging.org/
David A. Kekich
Maximum Life Foundation
"Where Biotech, Infotech and Nanotech
Â Â Â Â Meet to Reverse Aging by 2033"